Senior Manufacturing Systems Engineer - Manufacturing Systems and Integrated Technologies

Amgen

Haematology and Oncology

Thousand Oaks, CA - USA

Senior Specialist / Project Manager

Experteer Overview

In this role, you drive the operation, integration, and ongoing refinement of manufacturing systems within Amgen’s Manufacturing Operations Technology team. You will manage MES and related data systems across the ATO site, collaborating with global teams to standardize processes and ensure compliant, efficient manufacturing. You’ll lead incident investigations, support regulatory readiness, and push Industry 4.0 initiatives to boost capacity. This position offers hands-on impact across cross-functional partners and a pathway to shape Amgen’s digital manufacturing landscape.

Compensation / Benefits

Retirement and Savings Plan with company contributions
Group medical, dental, and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives

Responsibilities

Support and stabilize key manufacturing systems across multiple buildings and the ATO site
Manage system integrations and drive operational improvements
Champion business process improvements and digital initiatives leveraging AI and established platforms
Provide after-hours on-call support and troubleshooting for manufacturing technology
Lead major incident investigations and CAPA activities with root cause analysis
Maintain inspection readiness and SDLC validation for critical applications
Support regulatory inspections with data and on-site presentations
Lead Industry 4.0 initiatives to improve efficiency and capacity
Lead and train team members to develop multi-system competencies
Maintain CMDB accuracy and support change control discussions at CAB meetings
Support cyber resiliency initiatives and on-site, client-facing presence as needed
Collaborate with cross-functional teams and global MES/IDA teams for standardization and integration

Key requirements

Doctorate degree or Master’s degree with 2 years in Information Systems/Systems Engineering
or Bachelor’s degree with 4 years in Information Systems/Systems Engineering
or Associate’s degree with 8 years in Information Systems/Systems Engineering
or High school diploma / GED with 10 years in Information Systems/Systems Engineering
Experience with GxP computer systems in regulated environments is preferred
Strong troubleshooting, analytical, and data management skills
Experience with IT change control and validation of GxP systems
Proven communication and cross-functional collaboration abilities

leadership collaboration project management MES (Manufacturing Execution System)PI Historian Instrument Data Acquisition (IDA)

Description

In this role, you drive the operation, integration, and ongoing refinement of manufacturing systems within Amgen’s Manufacturing Operations …

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