Principal Statistician

Barrington James

Clinical and Theoretical Areas

London - Großbritannien

Senior Specialist / Project Manager

Hybrid

Experteer Overview

As Principal Statistician, you lead complex evidence-synthesis and HTA projects, shaping statistical strategy across high-impact programmes. You will partner with multidisciplinary teams, provide mentoring to developing statisticians, and drive methodological rigour. You translate advanced analyses into actionable insights for health-economic submissions. This role offers leadership and the opportunity to influence internal methodologies and SOPs within a collaborative, method-focused team. You will be at the forefront of HTA-driven evidence synthesis and methodological innovation.

Compensation / Benefits

flexible working culture
autonomy
interaction with senior leadership
exposure across therapeutic areas
influence on internal methodologies

Responsibilities

Design statistical analysis plans and feasibility assessments for advanced evidence-synthesis challenges
Code and run analyses including pairwise meta-analysis, NMAs (time-varying survival models), MAIC/PAIC, and IPD analyses
Oversee quality control to ensure rigour and reproducibility
Communicate complex statistical results to clients and cross-functional teams
Lead contributions to proposals, pitches, and development of internal methodologies, SOPs, and QC frameworks
Provide technical leadership, coaching, and mentorship to junior and mid-level statisticians

Key requirements

Significant experience leading evidence-synthesis statistical work (meta-analysis, NMA, indirect comparisons)
Proficiency in R with familiarity in Bayesian approaches (e.g., BUGS)
Strong track record in HTA-focused analyses and interpreting results for health economic models and submissions
Experience leading or mentoring statisticians and influencing analytical approaches
Clear and confident communication of complex statistical concepts to diverse audiences

leadership mentorship clear communication R Bayesian methods (BUGS)Network meta-analysis (NMA)

Description

As Principal Statistician, you lead complex evidence-synthesis and HTA projects, shaping statistical strategy across high-impact programmes.…

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