Director, Program Management I & I Full Life Cycle

Monte Rosa Therapeutics

Human Health and Social Work

Boston, MA - USA

Manager / Team Leader

Experteer Overview

In this role you will lead strategic and operational efforts for priority immunology and inflammation programs, guiding assets from mid- to late-stage development toward regulatory submission. You partner with Clinical, Regulatory, CMC, and other functions to ensure an integrated development plan aligned with the TPP/IDP, adapting as science evolves. You drive cross-functional execution, risk management, and portfolio prioritization in a fast-paced biotech setting. This is a hands-on leadership role that balances scientific rigor with speed and capital efficiency, delivering clear recommendations to executive stakeholders.

Responsibilities

Lead strategic and operational direction for immunology/inflammation programs, aligning clinical strategy with regulators
Develop and maintain cross-functional development plans across clinical, regulatory, CMC, manufacturing, and translational functions
Conduct scenario planning to evaluate development pathways, sequencing, acceleration, and capital-efficient trade-offs
Pressure-test timelines and critical paths; identify opportunities to streamline without compromising quality
Establish risk frameworks for biomarker, patient heterogeneity, regulatory complexity, and competitive shifts
Lead Global Program Team risk discussions and escalate high-impact issues
Develop contingency strategies for clinical, manufacturing, or regulatory inflection points
Monitor program budget and resource health relative to priorities
Clarify accountability and decision rights in a lean, matrixed biotech structure
Partner in long-range planning and portfolio prioritization; build real-time tracking tools (e.g., Smartsheet dashboards) for visibility
Prepare executive-ready materials distilling complex issues into actionable recommendations
Lead continuous improvement in Program Management to boost agility and execution discipline

Key requirements

12+ years in biotechnology/pharma drug development
Minimum 8 years leading cross-functional development teams in program/project management
Experience advancing immunology and/or inflammation assets through Phase 2/3
Experience supporting major regulatory interactions (End-of-Phase 2 meetings, NDA/BLA submissions)
Experience in small-to-mid-sized biotech environments requiring hands-on leadership

strong stakeholder influence in a matrixed environment high emotional intelligence excellent communication of complex topics to executives Smartsheet MS Project Teams

Description

In this role you will lead strategic and operational efforts for priority immunology and inflammation programs, guiding assets from mid- to …

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